iProtein A Purose 4 Fast Flow, iProtein A Purose LX, Rigose MabPureA, and Rigose MabPureA LX are AC media formed on high flow cross-linked agarose matrix and alkali-tolerant protein A-derived ligand. The ligand is the alkali-resistant modified protein A recombined and expressed by E. coli, which allows the use of 0.1-0.5 M sodium hydroxide for CIP. And the modified protein A has enhanced resistance to protease which can achieve lower ligand leakage. So, it is more suitable for the production and application in the downstream purification of antibody.